Increase in New MRI activity following CCSVI?

CCSVI - (Chronic Cerebro-Spinal Venous Insufficiency) is a term used to describe compromised flow of blood in the veins draining the central nervous system.

During 2008 – 2009, the renowned Italian Doctor Paolo Zamboni published a theory purporting that MS is caused by chronic cerebrospinal venous insufficiency (CCSVI).

Increase in New MRI activity following CCSVI?

Postby themsforum.org » Sat, 26 Jan 2013, 7:31 pm

Epub: Alroughani et al. Treatment of Chronic Cerebro-Spinal Venous Insufficiency in Multiple Sclerosis: A retrospective study. Int J Neurosci. 2013 Jan.

Background: Chronic Cerebro-Spinal Venous Insufficiency (CCSVI) has been proposed to be associated with Multiple Sclerosis (MS). Zamboni et al reported significant improvement in neurological outcomes in MS patients who underwent Percutaneous Transluminal Angioplasty (PTA).

Objectives: To retrospectively evaluate the neurological outcomes in MS patients who underwent PTA.

Method: Relapsing remitting MS patients who underwent PTA and completed at least one year post PTA were assessed. Patients with clinically isolated syndrome or progressive forms of MS were excluded. Primary endpoint was the proportion of relapse-free patients at one year. Secondary endpoints were change in mean EDSS score and proportion of patients with new MRI activity (defined as either Gadolinium-enhancing or new T2 lesions) at one year.

Results: 45 patients satisfied the inclusion criteria. Females constituted 71.1%. The mean age and mean disease duration were 33.76 and 7.16 years respectively. At one-year post-PTA, the proportion of relapse-free patients decreased from 84.44% to 66.67% (p = 0.085) whereas the mean EDSS score increased (p = 0.017). The proportion of patients with new MRI activity increased significantly from 17.78% to 44.44% (p = 0.012). 35.6% of patients stopped their DMTs. There was no difference among the patients who stopped their DMTs with respect to relapses, EDSS score or new MRI activity.

Conclusion: The study revealed that PTA in relapsing remitting MS patients was not associated with any neurological improvement. However, there was an increase in disease activity irrespective of the adherence to DMTs.
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